Development of an imaging system by Raman and fluorescence spectroscopy for endoscopic probes
Development of an imaging system by Raman and fluorescence spectroscopy for endoscopic probes
Sector
Medtech
Subject
Health Sciences – Cancer Diagnosis and Detection
Participants
Patrick Orsini, M.Sc.A. ing., Isabelle Dicaire, Ph.D., Jacques Bismuth, Ph.D., Marie-Maude de Denus-Baillargeon, Ph.D. Maroun Massabki, M.Sc.A., Keven Savard, Philippe McCoy
Partners
Polytechnique Montréal, Multitel (Belgique), Université de Strasbourg (France
As part of the AMARANTA project (Advanced Multichannel fluorescence And Raman dual-microscope: A New Tool for Biomedical Applications), we worked on the development of a Raman imaging system.
This surgical tool is designed for the in-vivo characterization of cancer tissue margins during brain surgery. Optech’s mandate and contribution to this project included the design of a new optical system to increase the field of view (FoV) up to 10 × 10 mm, as well as the integration of new functionalities into the existing system.
The device designed is composed of three subsystems: the probe in contact with the biological tissue, the laser injection system, and the Raman signal collection system.
The optical and optomechanical design, along with the prototyping of these three subsystems, was carried out in Optech’s laboratories before being tested on biological samples at the CRCHUM.
This proof-of-concept on biological samples validated the use and expected performance of the measurement device.
