Development of an imaging system by Raman and fluorescence spectroscopy for endoscopic probes

Optical fibers and sensors
Optical AI
Imaging and illumination

Development of an imaging system by Raman and fluorescence spectroscopy for endoscopic probes

Sector

Medtech

Subject

Health Sciences – Cancer Diagnosis and Detection

Participants

Patrick Orsini, M.Sc.A. ing., Isabelle Dicaire, Ph.D., Jacques Bismuth, Ph.D., Marie-Maude de Denus-Baillargeon, Ph.D. Maroun Massabki, M.Sc.A., Keven Savard, Philippe McCoy

Partners

Polytechnique Montréal, Multitel (Belgique), Université de Strasbourg (France

Date

December 3, 2020

As part of the AMARANTA project (Advanced Multichannel fluorescence And Raman dual-microscope: A New Tool for Biomedical Applications), we worked on the development of a Raman imaging system.

This surgical tool is designed for the in-vivo characterization of cancer tissue margins during brain surgery. Optech’s mandate and contribution to this project included the design of a new optical system to increase the field of view (FoV) up to 10 × 10 mm, as well as the integration of new functionalities into the existing system.

The device designed is composed of three subsystems: the probe in contact with the biological tissue, the laser injection system, and the Raman signal collection system.

The optical and optomechanical design, along with the prototyping of these three subsystems, was carried out in Optech’s laboratories before being tested on biological samples at the CRCHUM.

This proof-of-concept on biological samples validated the use and expected performance of the measurement device.

Development of an imaging system by Raman and fluorescence spectroscopy for endoscopic probes