As part of the AMARANTA (Advanced Multichannel fluorescence And Raman dual-microscope: A New Tool for biomedical Applications) project, we worked on the development of a Raman imaging system.
This surgical tool is designed for in-vivo characterization of cancerous tissue margins during brain surgery. Optech’s mandate and contribution to this project consists in particular of designing a new optical system with the aim of increasing the field of view (FoV) up to 10 x 10 mm as well as adding new functionalities to the already existing system.
The equipment thus designed consists of three subsystems including the probe in contact with biological tissue, the laser injection system and the Raman signal collection system.
The optical, optomechanical design and prototyping of these three subsystems were carried out in Optech’s laboratories before being tested on biological samples at CrCHUM.
This demonstration in principle on biological samples validates the use and expected performance of the measurement device.
Several validations are underway to complete functionality testing and begin clinical testing on patients.
What’s in it for me? The project’s expertise in probe design for the medical sector has enabled Optech to expand its expertise in this field. This product development expertise is also applicable in other fields such as aerospace and industry.
Jean-Bernard Lecourt, Fabian Dortu, Chems-Eddine Ouinten, Yves Hernandez “Switchable dual wavelength picosecond fiber laser source operating around 780 nm for advanced Raman spectroscopy”,2019 (publié le 4 mars 2021), SPIE Digital Library
François Daoust,1,2 Tien Nguyen,1,2 Patrick Orsini,3 Jacques Bismuth,3 Marie-Maude de Denus-Baillargeon,3 Israel Veilleux,1,2 Alexandre Wetter,3 Philippe McKoy,3 Isabelle Dicaire,3 Maroun Massabki,3 Kevin Petrecca,4 Frédéric Leblond1,2, “Handheld-macroscopic-Raman-spectroscopy-imaging-instrument-for-machine-learning-based”, (publié le 12 février 2021), SPIE Digital Library